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Although often considered one of the positive effects of GLP-1 RAs, some users complain about low appetite

This dual activation may provide additional metabolic benefits for patients with insulin resistance or metabolic inefficiency, though response depends on individual genetics and baseline metabolic function

The same result was obtained in the active controlled studies (WMD = 2.37 kg, 95% CI 0.30 to 4.44, P = 0.02, I 2 = 0%), while there is no statistically significant distinction observed between the two subgroups ( P = 0.55) (Additional file 2: Fig

Comparing tirzepatide to other weight loss approaches Understanding where tirzepatide fits in the broader landscape of weight loss interventions helps frame expectations appropriately